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Regulation of T cell immunity by cellular metabolism

Zhilin Hu, Qiang Zou, Bing Su

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2

Abstract:

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.

Keywords： T cell immunity metabolic pathways nutrient uptake metabolic checkpoints

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: Multiple factors may be involved in the cellular regulation of PP2A activity.

Keywords： hyperphosphorylation PP2A activity cellular regulation siRNA siRNA transfection

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Parametric sensitivity analysis of cellular diaphragm wall

Xi CHEN, Wei XU

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 4, Pages 358-364 doi: 10.1007/s11709-012-0177-3

Abstract: The deformation law of the cellular diaphragm wall in deep foundation pits was studied through numericalInteraction between the cellular diaphragm wall and the soil was also taken into account in the calculationThe centrifuge model test was carried out to study the deformation regulation for a cellular diaphragmIn the end, a suggestion was proposed to optimize the cellular diaphragm by adjusting the length of the

Keywords： cellular diaphragm wall sensitivity analysis optimization centrifuge model test

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: The liver has a complex cellular composition and a remarkable regenerative capacity.The regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydratesrecent years, with the rapid development of genetic sequencing technologies, research on the liver’s cellularThis review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources

Keywords： liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies

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Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services

Lian-fu Jiang,Guo-xian Xu,Hao Jiang

Frontiers of Engineering Management 2014, Volume 1, Issue 4, Pages 395-401 doi: 10.15302/J-FEM-2014058

Abstract: target city was simulated using Arc GIS and Geo SOS software basing on multi-criteria decision model of Cellular

Keywords： Ecosystem service function optimization of land use Cellular Automata (CA)

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Moving policy and regulation forward for single-use plastic alternatives

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-021-1423-5

Abstract: Single-use plastics are often used once or cannot be reused for extended periods. They are widely consumed with the rapid development of social economy. The waste generated by single-use plastics threatens ecosystem health by entering the environment and ultimately restricts sustainable human development. The innovation of sustainable and environmentally friendly single-use plastic alternative materials and the joint participation of governments, enterprises and the public are promising technologies and management approaches that can solve the problem of single-use plastics wastes. The development of single-use plastic alternative products can be promoted fundamentally only by improving relevant legislation and standards, providing differentiated industrial policies, encouraging scientific and technological innovation and expanding public participation.

Keywords： Single-use plastic alternatives Policy Regulation Sustainable development

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Phase transition regulation and caloric effect

Frontiers in Energy 2023, Volume 17, Issue 4, Pages 463-477 doi: 10.1007/s11708-023-0860-1

Abstract: Solid state refrigeration based on caloric effect is regarded as a potential candidate for replacing vapor-compression refrigeration. Numerous methods have been proposed to optimize the refrigeration properties of caloric materials, of which single field tuning as a relatively simple way has been systemically studied. However, single field tuning with few tunable parameters usually obtains an excellent performance in one specific aspect at the cost of worsening the performance in other aspects, like attaining a large caloric effect with narrowing the transition temperature range and introducing hysteresis. Because of the shortcomings of the caloric effect driven by a single field, multifield tuning on multicaloric materials that have a coupling between different ferro-orders came into view. This review mainly focuses on recent studies that apply this method to improve the cooling performance of materials, consisting of enlarging caloric effects, reducing hysteresis losses, adjusting transition temperatures, and widening transition temperature spans, which indicate that further progress can be made in the application of this method. Furthermore, research on the sign of lattice and spin contributions to the magnetocaloric effect found new phonon evolution mechanisms, calling for more attention on multicaloric effects. Other progress including improving cyclability of FeRh alloys by introducing second phases and realizing a large reversible barocaloric effect by hybridizing carbon chains and inorganic groups is described in brief.

Keywords： phase transition regulation caloric effect solid state refrigeration

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The function and regulation of OTU deubiquitinases

Jiansen Du, Lin Fu, Yingli Sui, Lingqiang Zhang

Frontiers of Medicine 2020, Volume 14, Issue 5, Pages 542-563 doi: 10.1007/s11684-019-0734-4

Abstract: Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processescharacter, structure and function of OTUs, such as the substrate specificity and catalytic activity regulation

Keywords： ubiquitin OTU deubiquitinases structure function regulation

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Influence of construction-induced damage on the degradation of freeze–thawed lightweight cellular concrete

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3, Pages 781-792 doi: 10.1007/s11709-021-0733-9

Abstract: During the construction of lightweight cellular concrete (LCC), material damage frequently occurs, causing

Keywords： lightweight cellular concrete construction-induced damage freeze-thaw action microstructure degradation

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Macro-architectured cellular materials: Properties, characteristic modes, and prediction methods

Zheng-Dong MA

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 3, Pages 442-459 doi: 10.1007/s11465-018-0488-8

Abstract:

Macro-architectured cellular (MAC) material is defined as a class of engineered materials having configurableseparated the strain field into a homogenized strain field and a strain variation field in the local cellularcharacteristic modes and the stress recovery process used to predict the stress distribution inside the cellular

Keywords： architectured material cellular materials multi-scale modeling homogenization method effective material

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A review of intelligent optimization for group scheduling problems in cellular manufacturing

Frontiers of Engineering Management Pages 406-426 doi: 10.1007/s42524-022-0242-0

Abstract: time of equipment, broaden the productivity, and enhance the flexibility of manufacturing, especially cellular

Keywords： cellular manufacturing group scheduling flowshop literature review

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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4, Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: Nanocarriers have been designed to enhance their cellular uptake via endocytosis but following theircellular uptake, endosomal escape is the rate limiting step which restricts the value associated withFinally, we highlight the important design elements of recent virus-based nanocarriers for efficient cellular

Keywords： nanocarrier cellular uptake endosomal release nucleic acid drug

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Quantum-dot cellular automata based reversible low power parity generator and parity checker design for

Jadav Chandra DAS,Debashis DE

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 3, Pages 224-236 doi: 10.1631/FITEE.1500079

Abstract: Quantum-dot cellular automata (QCA) is an emerging area of research in reversible computing.

Keywords： Quantum-dot cellular automata (QCA) Parity generator Parity checker Feynman gate Nanocommunication

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2, Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizingcause the human genetic disease ataxia telangiectasia, encodes a key protein kinase that controls the cellular

Keywords： ataxia-telangiectasia mutated (ATM) cell cycle checkpoint DNA damage signalling transduction